CAS 78-39-7 Triethyl Orthoacetate Nicotine And Pyrethroid Intermediates For Dyes Pharmaceutical Industry

CAS 78-39-7 Triethyl Orthoacetate 1,1,1-Triethoxyethane Intermediate For Dyes And Pharmaceutical Industry

Basic Information

Product Parameters

Packaging Types

30KG plastic bucket ; 200 KG barrel ; 1-ton IBC tote or as per customers' requirement

Storage Information

It can be sealed and packed in plastic-lined iron drums, and stored in a dry, well-ventilated environment at room temperature. Avoid mixing and transporting with acids and oxides. Keep away from fire and heat sources and avoid rain and exposure.

Applications

Resolve resolution

Triethyl orthoacetate is reacted with ethanol using acetonitrile in the presence of hydrogen chloride to generate imidate, and then alcoholysis to obtain triethyl orthoacetate. The reaction equation is as follows:
The reaction process is divided into three steps. The first step is the production of imidate, and the reaction is carried out in toluene solution. Equal moles of acetonitrile and absolute ethanol are dissolved in toluene, and anhydrous hydrogen chloride is continuously introduced for about 2 hours at a temperature of -5~0℃, and then reacted at room temperature for 36~48 hours. The amount of hydrogen chloride introduced is 1.1 moles of acetonitrile. Times. The reaction produces a large amount of crystalline product, which is imidate.
The second step is the alcoholysis reaction. The amount of absolute ethanol added is 3 times the mole of acetonitrile. At 40°C, about 20 hours of alcoholysis, the reaction process uses thymol blue as an indicator and slowly adds ammonia until the liquid is slightly Until the red turns into a stable yellow, the pH value of the feed liquid is between 5-6.
In the third step, the product is separated, and the material liquid is poured into ice water with a certain amount of ammonia water, stirred and washed thoroughly to dissolve the by-product of ammonium chloride. Separate the water layer and separate the water layer. The oil layer is dried with anhydrous potassium carbonate and then distilled. First, the solvent is evaporated, and the fraction at 142~148℃ is the triethyl orthoacetate product. The yield is more than 72%. If the high temperature solvent is used, the yield is expected to increase to 80%.

Company Profile

Wuxi High Mountain Hi-tech Development Co., Ltd is a professional industrial company engaged in special

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