Sodium Chloroacetate 3926‑62‑3 SMCA for Water Soluble Alkylation Reagent in Fine Chemical Manufacture

SMCA Toxicokinetics and Metabolism

Sodium Chloroacetate (C₂H₂ClNaO₂, CAS 3926‑62‑3) rapidly metabolizes to monochloroacetic acid (MCA) after ingestion. In rats, oral exposure leads to liver and kidney accumulation via metabolites like thiodiacetic and glycolic acids benchchem.com+4tera.org+4highmountainco.com+4. This highlights the compound’s systemic distribution and organ-specific impacts.

2. Acute Toxicity Profiles

• Oral LD₅₀ values range from 76–580 mg/kg in rodents, indicating moderate acute toxicity .

• Inhalation and dermal data are limited, but Fisher’s SDS reports it may be fatal if absorbed through skin or inhaled pubchem.ncbi.nlm.nih.gov.

• Exposure symptoms include skin corrosion, respiratory distress, convulsions, nausea, and abdominal pain tera.org+14highmountainco.com+14pubchem.ncbi.nlm.nih.gov+14.

3. Chronic Exposure and Health Effects

Long-term exposure may impair liver and renal function, damage fertility, and harm fetal development chemicalsafety.ilo.org+2ecetoc.org+2echa.europa.eu+2.
A 90-day rat study identified a LOAEL at 15 mg/kg/day, suggesting caution with repeated exposure pubchem.ncbi.nlm.nih.gov+12tera.org+12ecetoc.org+12.

4. Occupational Exposure Limits and Monitoring

• The WEEL guideline suggests a TWA of 0.5 ppm (2.5 mg/m³) over 8 hours highmountainco.com+7tera.org+7nj.gov+7.

• The German MAK (inhalable) limit is 2 mg/m³, also noting significant skin absorption risk chemicalsafety.ilo.org+1highmountainco.com+1.

• Acute exposure guidelines (e.g., AEGL-1) range from 0.83 ppm (12ppm short-term) elchemy-website.s3.ap-south-1.amazonaws.com+1highmountainco.com+1.

5. First Aid and Medical Response

• Ingestion: Rinse mouth; do not induce vomiting; seek medical care hpvchemicals.oecd.org+2highmountainco.com+2fishersci.co.uk+2.

• Skin contact: Rinse with water; remove contaminated clothing; consult a physician .

• Inhalation: Move to fresh air; get medical attention if symptoms persist highmountainco.com.

• Eyes: Flush with water for 15+ minutes; seek immediate medical attention.

6. Regulatory Classifications

GHS & EU CLP

• Acute Tox. 3 (H301): Toxic if swallowed

• Skin Irrit. 2 (H315)

• Eye Irrit. 2 (H319)

• Aquatic Acute 1 (H400) – very toxic to aquatic life downloads.regulations.gov+12fishersci.co.uk+12canada.ca+12

Transport

• UN 2659, Hazard Class 6.1 (Poisonous), Packing Group III echa.europa.eu+3hpvchemicals.oecd.org+3highmountainco.com+3

7. Safe Handling & PPE

• Use local exhaust or fume hoods when handling powders or solutions.

• PPE: respirator (NIOSH-approved dust/mist), chemical-resistant gloves, goggles, lab coat or coveralls .

• Conduct air monitoring; perform routine medical check-ups if use is sustained.

8. Internal Link: HighMountainChem Availability

For information on technical-grade and analytical-grade Sodium Chloroacetate, including safety datasheets and packaging, visit HighMountainChem’s product page:
https://highmountainchem.com/sodium-chloroacetate-cas-3926-62-3/

Packaging Types

25kg/ drum or as per customers ' requirements .

Transport/Storage Information

Sealed and stored in a dry place.

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