Sodium Chloroacetate (SMCA), C₂H₂ClNaO₂, CAS 3926‑62‑3, is valued not just as a chemical intermediate but also for its emerging applications in drug delivery, polymeric biomaterials, and cytotoxicity assays zh.wikipedia.org+10benchchem.com+10highmountainco.com+10.
Research shows SMCA is biocompatible and capable of modifying polymer matrices to enable controlled drug release. Specific studies using biodegradable carriers achieved sustained release profiles for therapeutic agents—highlighting SMCA’s potential in smart delivery platforms benchchem.com.
SMCA demonstrates dose-dependent cytotoxicity in cell models (e.g., opossum kidney and Chang liver cells). It inhibits enzymes like glyceraldehyde‑3‑phosphate dehydrogenase, leading to metabolic stress with IC₅₀ in the sub-millimolar range (~0.3 mM) benchchem.com.
As an alkylating agent, SMCA transfers the –CH₂CO₂⁻ group to nucleophiles within biological molecules. This process can disrupt metabolic enzymes and affect signaling pathways when applied at appropriate concentrations zh.wikipedia.org+11benchchem.com+11ontosight.ai+11.
Unlike monochloroacetic acid, which is highly corrosive and hazardous, SMCA is less corrosive and considered non-sensitizing in skin tests en.wikipedia.org+4tera.org+4procurementresource.com+4. Still, it requires careful dosing in biomedical settings to avoid unwanted cytotoxicity.
For researchers developing SMCA-based polymers or delivery systems, HighMountainChem provides analytical-grade and pharmaceutical-grade SMCA with technical data sheets and safety documentation:
https://highmountainchem.com/sodium-chloroacetate-cas-3926-62-3/
This article incorporates high-value terms—Sodium Chloroacetate, SMCA, drug delivery, cytotoxicity, biocompatibility, alkylating agent, and Smart polymers—to guide professionals investigating SMCA’s role in advanced biomedical research.
Company Profile
Wuxi High Mountain Hi-tech Development Co., Ltd is a professional industrial company engaged in special
chemical production, technology research & development, and import & export. The company focuses on
the production, trade, and research & development of various chemical products.
Since establishment, the company has been concentrating on constructing an international marketing
network and optimizing supply chain management, where we have established a long-term strategic
cooperation relationship with numerous large enterprises at home and abroad. Relying on our wide business
channels and professional experience, we are more skillfully providing products of stable but differentiated
quality, along with flexible, highly efficient & considerate service to satisfy our partner at more competitive pricing.
Efficiently treating our customers as partners with sincerity, specialization and satisfaction is our managerial
principle. Attributed to the backup of a dedicated technical team, filled with wide and profound knowledge
and practice in chemicals and world trade for 20 years, the company owns rich experience in product quality
control, technical solution, chemical logistics organization, packaging optimization, port operation, etc., which
accounts for its first-class cost control management and ensures to maintain the overwhelming competitive
advantage over others. In line with the principle of sharing the preferential cost and joint development, the
company has formed an interesting community for years with its customers at home and abroad. Sincerely
to build up a pleasant mutual trust, cooperative, win-win, and value-added sustainable partnership is what
we are achieving to grow together with you!
Our products are sold all over the world, you can rest assured.
