SMCA Sodium Monochloroacetate 98 Purity Raw Material for Carboxymethyl Cellulose Polymer Additives

Introduction to SMCA in Biomedicine

Sodium Chloroacetate (SMCA), C₂H₂ClNaO₂, CAS 3926‑62‑3, is valued not just as a chemical intermediate but also for its emerging applications in drug delivery, polymeric biomaterials, and cytotoxicity assays zh.wikipedia.org+10benchchem.com+10highmountainco.com+10.

2. SMCA in Drug Delivery Systems

Research shows SMCA is biocompatible and capable of modifying polymer matrices to enable controlled drug release. Specific studies using biodegradable carriers achieved sustained release profiles for therapeutic agents—highlighting SMCA’s potential in smart delivery platforms benchchem.com.

3. Cytotoxic and Enzyme-Inhibition Effects

SMCA demonstrates dose-dependent cytotoxicity in cell models (e.g., opossum kidney and Chang liver cells). It inhibits enzymes like glyceraldehyde‑3‑phosphate dehydrogenase, leading to metabolic stress with IC₅₀ in the sub-millimolar range (~0.3 mM) benchchem.com.

4. Mechanism of Cellular Action

As an alkylating agent, SMCA transfers the –CH₂CO₂⁻ group to nucleophiles within biological molecules. This process can disrupt metabolic enzymes and affect signaling pathways when applied at appropriate concentrations zh.wikipedia.org+11benchchem.com+11ontosight.ai+11.

5. Comparative Safety vs. Parent Acid (MCA)

Unlike monochloroacetic acid, which is highly corrosive and hazardous, SMCA is less corrosive and considered non-sensitizing in skin tests en.wikipedia.org+4tera.org+4procurementresource.com+4. Still, it requires careful dosing in biomedical settings to avoid unwanted cytotoxicity.

6. HighMountainChem Biomaterial Solutions

For researchers developing SMCA-based polymers or delivery systems, HighMountainChem provides analytical-grade and pharmaceutical-grade SMCA with technical data sheets and safety documentation:
https://highmountainchem.com/sodium-chloroacetate-cas-3926-62-3/

7. SEO-Optimized Summary

This article incorporates high-value terms—Sodium Chloroacetate, SMCA, drug delivery, cytotoxicity, biocompatibility, alkylating agent, and Smart polymers—to guide professionals investigating SMCA’s role in advanced biomedical research.

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